The basal region of sound-exposed cochleae frequently exhibited changes in vessel diameter and increased loading of GTTR or gentamicin in a subset of marginal cells, after chronic moderate or intense sound exposure.
Following gp120 injection into the blood we observed a subset of marginal zone cells that rapidly acquired the gp120 signal.
Consistently, we observed a negative correlation with age in the two naive B cell subsets that exhibit suspected regulatory properties – CD5+ B cells (ρ = −0·428, P = 2·21 × 10−4) and CD19+CD27−CD24hiCD38hi B cells (ρ = −0·558, P = 9·09 × 10−9), while the memory subset of marginal zone B cells showed a positive correlation with age (ρ = 0·339, P = 1·01 × 10−3; Fig. 5d f and Table 3).
10.7554/eLife.06467.007 Figure 2. IFC cell processes bearing gp120 directly contact B cells and a subset of splenic marginal zone cells also bind gp120.
Differences in the structure of P between these central and marginal populations indicate that a unique subset of phenotypic space is accessible to selection in these marginal populations [ 16].
They tweaked the credit-scoring software of a microfinance firm so that only a random subset of people with marginal credit histories were accepted as clients.
A de-identified data set is considered valid if it preserves (i) means and co-variances in a small subset of records, (ii) marginal values in a few tabulations of the data, and (iii) at least one distributional characteristic.
As is commonly done, we intend to detect marginal treatment effects on a selected subset of eligible subjects so that a manageable sample size can be used to conduct the study in a timely manner.
We ran MISA using the 77 SNPs that passed the screen with parameters a = 1/8 and S = 77, which leads to marginal prior odds of association in this subset of 1/axS = 0.0016.
One common approach is the reduction of the search space, usually by filtering candidate loci pairs: Marchini et al. (2005) suggested selecting a subset of SNPs with a moderate marginal effect and testing for interaction in pairs where at least one locus is included in the subset.
