Since C2A and C2B have marginal stability, the ease with which ligands or binding partners cause a structural change in Syt I increases.
The Ivantsov solution with marginal stability arguments (IMS model) is a widely used model that relates dendrite growth velocity to total undercooling for dilute alloy systems.
Denatured 1b11 polypeptides fold into transient, folded monomers with marginal stability (ΔG<1 kcal mol−1) which convert rapidly (≈6×104 M−1 s−1) into dimers (ΔG=9.8 kcal/mol) and then more slowly (≈3 M−1 s−1) into tetramers (ΔG=28 kcal mol−1).
This marginal stability is also observed with natural proteins, which can be modified to have higher stabilities while retaining native-like activities (Serrano et al. 1993; Giver et al. 1998; Van den Burg et al. 1998; Zhao and Arnold 1999; Korkegian et al. 2005).
These results suggest that a burst-phase intermediate with even marginal stability does not exist.
A time-domain model has also been developed for nonlinear analysis, and the system marginal stability boundaries calculated by this method is consistent with those by frequency domain method.
According to marginal stability analysis [ 28], the propagation front moves with the minimum possible speed.
Using the quantitative, thin-interface formulation of the problem we have found that at high Lewis number a minimum in the dendrite tip radius is predicted with increasing undercooling, as predicted by marginal stability theory.
Importantly, it reproduces many known properties of proteins and their evolution, such as the observed marginal stability, the higher rate of evolution of exposed locations compared with buried locations, the tendency for hydrophobic residues to cluster in the interior, the dependence of protein stability on population size, and over-dispersion of the molecular clock (Goldstein 2011).
When coupled in feedback with the pilot biodynamics, such delay may lead to marginal stability conditions or even to instability.
