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However, APP-BP1 expression appeared to be reduced by P12 (Fig. 6D), and only a marginal signal was found in the adult brains (Fig. 6E).
We found a moderate, ubiquitous level of APP-BP1 mRNA signal in developing embryonic and early postnatal brains (Fig. 6A D), but APP-BP1 expression appeared to be reduced by P12 (Fig. 6D), and only a marginal signal of APP-BP1 was found in the adult brain (Fig. 6E).
While the inflamed muscles showed diffused, patchy or marginal signal abnormalities on MRI, FDG uptake was most prominent inside the muscles.
Ratios were defined as marginal signal intensity when there was a substantial amount of variation in the signal intensity within the pixels from 800 to 1,500.
At the experimental setting (α1 = 0.04, α2 = 0.06, τ = 0.015), the marginal signal intensity (M) was approximately 2.2%, thereby confirming the reliability of the microarrays.
Genes in bold were selected for candidate gene analyses by qRT-PCR.; # marginal signal intensity; NCBI, National Center for Biotechnology Information GBB, GenBank.
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Therefore, considerable technology development is an immediate priority, along with parallel advances in bioinformatics and biostatistics systems aimed at discriminating between marginal signals and background noise within extremely large, diverse and complex data sets.
In this extreme case, traditional methods that use marginal signals will not find these two genes important.
Out of 83 differentially expressed transcripts between both cell lines, 79 corresponded to absent or marginal signals, leaving only 4 differentially expressed transcripts.
The marginal signals in a few cell lines seen with monoclonal 1C10 antibody most probably represents unspecific background, which was eventually similar in quality but inferior in quantity as compared to JFC12T10.
It was hypothesized that when the target odor is not present, then sniffing duration will be shorter (true negatives and possibly some false positives), and that dogs will be more likely to reinvestigate marginal signals they perceive as inconclusive before issuing a response (false negatives and some false positives).
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