Sentence examples for marginal side effects from inspiring English sources

Recently, Charlotte Kristensen et al. reported that introducing the sorghum pathway for biosynthesis of the cyanogenic glucoside dhurrin into Arabidopsis plants resulted in high dhurrin levels and only marginal side effects on the metabolome and the transcriptome.

Due to this marginal benefit with added side effects in the maintenance setting, the FDA did not approve ridaforolimus for this indication.

Clinical trials of vasopressin and mTOR antagonists have shown marginal efficacy and important side effects, despite showing promising preclinical efficacy for several of our investigated parameters, in rodent models closely related those employed here.

Conclusions: Treatment with tamoxifen added only marginal benefit while causing unacceptable side effects.

However, most treatments often bring side effects with marginal results and have population-specific efficacy.

However, due to the marginal benefit and the severe side effects accomplished with aromatase inhibitor therapy, tamoxifen still plays an important role in breast cancer treatment.

The shorter duration of administration without the need of a steroid premedication and lack of cumulative side effects with marginal cardiac toxicity provide strong argument for its choice as the control arm in future phase III trials including trastuzumab-based combinations.

The absolute cost of GWASs in pharmacogenomics remains as high as in other fields, but in the context of drug RCTs and observational studies for side effects, the marginal cost of genotyping is small: as Roses recently pointed out [ 20], the entire investment in DNA sample collection and genotyping up to now is only a small fraction of the currently estimated cost to develop a single drug.

Other side effects were only marginal and did not require cessation of therapy.

This drug has only marginal efficacy, often leads to gastro-intestinal side effects, and sometimes causes severe liver damage.

Several PKD clinical trials assessing drugs that target these pathways, however, have suggested only marginal efficacy, in the face of appreciable side effects [ 7- 9].