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Expression of hUCP3 at moderate levels in adult neurons led to a marginal lifespan-extension in males.
We find that high, ubiquitous expression of hUCP3 does not increase lifespan, while adult-specific neuronal expression causes a marginal lifespan-extension only in males.
Riluzole may have a marginal effect, prolonging lifespan by a few months.
When Drosophila fly food was supplemented with turmeric (0.25 g, 0.5 g, and 0.7 g per 100 mL of media), there was a marginal increase in lifespan at a lower concentration (0.25 g/100 mL).
Predicted gene numbers for both families showed only marginal association with maximum lifespan.
For this reason, it is important to determine whether a marginal level expression can improve life quality and prolong lifespan.
We note, however, that if the lifespan of colonies were heterogeneous the marginal distribution of survival times would no longer be exponential and estimates of half-life less meaningful.
Indeed, an underlying morbidity pattern as stable as that seen in Fig. 7 would predict improvements in the marginal chronological age pattern of self-reported health if the lifespan distribution were to shift to higher ages.
However, such an increasing pattern over age is a marginal artifact, due to an interaction between the distribution of lifespans and the relatively fixed underlying pattern of morbidity seen in Fig. 7.
Marginal survival has been reported in severely impaired or bedridden patients [18, 24, 30], as well as in patients with no lifespan prolonging anticancer therapy [19].
Marginal Christians.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com