For another, the minutes to December's meeting show that most policy makers think "the marginal efficacy of [bond] purchases was likely declining as purchases continue".
Apart from negative feedback mechanisms, the major reason of marginal efficacy of IL-12 in cancer patients, as opposed to animal tumor models, was probably strong immunosuppressive milieu, typical for tumor microenvironment in humans.
Cytotoxic chemotherapy, hormonal agents, and immunotherapy have been tested in HCC with marginal efficacy to date.
Cytotoxic chemotherapy and hormonal agents have been tested in HCC with marginal efficacy to date.
Several PKD clinical trials assessing drugs that target these pathways, however, have suggested only marginal efficacy, in the face of appreciable side effects [ 7- 9].
However, failures in many large clinical trials using A β-targeted drugs (Table 4) and FDA approved compounds with marginal efficacy questioned the validity of A β cascade hypothesis.
Due both to safety concerns, which include hypotension, syncope, somnolence, fatigue, and potential carcinogenicity and to the short duration of studies and questionable accuracy of 4 week recall along with marginal efficacy, approval was denied and additional safety studies recommended.
Clinical trials of vasopressin and mTOR antagonists have shown marginal efficacy and important side effects, despite showing promising preclinical efficacy for several of our investigated parameters, in rodent models closely related those employed here.
For other autoimmune diseases that are in dire need of safer and/or more effective therapies, the anti-BAFF antibody belimumab, despite showing marginal efficacy in clinical trials, was approved for treatment of systemic lupus erythematous (SLE).
The two algorithms achieving any semblance of prediction accuracy did so by predicting some of the canonical interactions with known marginal efficacy.
Its successor drug, oxcarbazepine, as well as other sodium-channel blockers, such as valproate, mexiletine, topiramate, and lamotrigine, showed only marginal efficacy and have not been licensed for the treatment of painful diabetic neuropathy.
