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A marginal dose of 13 Gy or greater was found to be a significant predictor of improved PFS.
Next, we performed an allotransplantation of a marginal dose of WT islets in recipient Erα−/− mice followed by treatment with vehicle or PPT.
A marginal dose of 1,000 islet equivalents (IEQ) of human islets were transplanted under the kidney capsule of recipient mice.
To explore this hypothesis, we used an insulin-deficient model with xenotransplantation of a marginal dose of human islets in nude mice rendered diabetic with streptozotocin.
Here, we used an insulin-deficient mouse model with xenotransplantation of a marginal dose of human islets to test the hypothesis that oestrogens improve islet engraftment during PIT.
In these mice, we performed either sham transplantation or xenotransplantation of a marginal dose of human islets (1,000 IEQ) under the renal capsule (PIT).
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Marginal doses of 20 25 Gy to the 50 % isodose were reported to be effective for seizure control.
Mean maximal and marginal doses of GKS were 36.4 Gy (range, 24 50 Gy) and 18 Gy (range, 14 25 Gy) prescribed to the 50% iso-dose line.
Seven patients received SRS alone, the median maximal and marginal doses of SRS were 34 Gy (range, 30-38 Gy) and 16 Gy (range, 14-20 Gy).
An early, small series reviewed 14 VS patients, initially with serviceable hearing (GR I or II) before CK, received mean marginal doses of 17 Gy in 1 3 sessions (prescribed dose 11.3 Gy).
Treatment volume for a single metastasis was defined as the volume of brain tissue receiving at least the prescribed marginal dose for that target lesion.
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