The introduction of a new clinical protocol (Basiliximab induction with calcineurin-sparing protocols) for a group of kidney transplant recipients receiving organs from marginal donors was validated with a Markov simulation model, demonstrating the usefulness of combining simulation with Bayesian estimation methods for analysis of cost-effectiveness data collected alongside a clinical trial.
The introduction of a new clinical protocol (basiliximab induction with calcineurin-sparing protocols) for a group of kidney transplant recipients receiving organs from marginal donors was validated with a Markov simulation model.
In fact, an increasing number of transplantations are performed with lungs from marginal donors, and the complex clinical settings often preclude full understanding of new treatment modalities cause-effect relationships.
The modern era of organ transplantation, which increasingly uses organs from marginal donors including those compromised by prior warm ischemia, is reliant on preservation technology to stabilize and even resuscitate the donor organ.
The modern era of organ transplantation, which increasingly uses organs from marginal donors including those compromised by prior warm ischemia, is reliant on preservation technology to provide the means to stabilize and even resuscitate the donor organ.
Future prospective, randomized clinical studies and studies that include a sufficient number of marginal donors will be required to elucidate the effects of BD on marginal liver grafts, and to select the most appropriate marginal organs for transplant.
The difference between the survival of the two receiving groups is not such to justify the exclusion of marginal donors from the 'pool' of potential kidney donors.
Considering that, the use of marginal donors can be a valid system in order to supply the lack of organs.
The disparity between supply of deceased donors and demand has increased in the last decades and has led to the increased use of organs from marginal donors, mostly in form of expanded criteria donor (ECD) kidneys [ 1– 7].
As a method of increasing the organ utilization we have expanded the acceptance criteria for marginal donors, so that in our region we transplant two marginal DCD kidneys into a single recipient (dual renal transplant).
