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Among the JMJD2 family members we tested, JMJD2A and 2B exhibited robust interactions with ER (Figure 3); however, in contrast to depletion of JMJD2B, depletion of JMJD2A caused only a marginal defect in ER target gene induction (Figure 4).
The main cause of failure for both types of restorations was total loss (9.3%), followed by gross marginal defect (5.4%).
However, the report further showed that depletion of JMJD2A caused only a marginal defect in ERα target gene induction, indicating that JMJD2A interaction with ERα was not robust.
If a tooth or restoration showed multiple defects, a marginal defect dominated an over- or underfilled restoration (10, 11 > 12, 13), secondary caries dominated a marginal defect (20, 21 > 10, 11), absence of a restoration dominated secondary caries (30 > 20, 21), and an overfilled cavity dominated an underfilled cavity (13 > 12).
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Indeed, the result of this study indicated that teeth presented with unsatisfactory tooth/restoration margin (due to marginal defects, fractures, or recurrent caries) would suffer from a less favorable outcome than those with satisfactory margins.
This study was designed to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with poly D, L lactic-co-glycolic acid (PLGA)/gelatin sponge complex (PGS) on the formation of bone in critically sized marginal defects of the mandible in dogs.
To demonstrate the synergistic enhancement, we induced dsRNAs weakly for either dVps15 or Rbsn-5 to induce only marginal defects (Fig. 8D).
Thus, the M2Y129F mutant displayed only marginal defects on tyrosine phosphorylation when compared to its wild type counterpart (Fig. 1A, upper panel), indicating that this site is not the main target of Fyn.
Main failure characteristics were secondary caries and gross marginal defects.
Depth of marginal defects was measured using a CPI probe.
Main failure characteristics were gross marginal defects and total or partial losses.
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