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However, independently of whether BVZ was given as early treatment or as late treatment at recurrence, only a marginal, clinical difference in median OS was seen as compared to the OS observed following standard treatment, as originally published by Stupp et al. 1 This indicates that BVZ in general does not influence OS in patients with GBM.
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The marked increase in sample size of RCTs provides statistical power to detect treatment differences between arms that are statistically significant but of marginal clinical relevance.
However, the mean difference in survival between the CMR arm and the other groups was only 4 weeks and thus of marginal clinical significance.
At his 2-week assessment, he reported marginal clinical improvement.
This may provoke further pathology when findings of marginal clinical significance are reported.
An increased ANB angle of less than 2o was, however, regarded as having marginal clinical significance.
*p<0.05, after logistic regression, controlling for marginal group difference in education.
Being more physically active showed a marginal significant difference (P = 0.08).
‡p value, after analysis of covariance, controlling for marginal group difference in education.
Finally, it is unknown if the marginal difference in mean weight loss (3.6 kg) is of clinical importance.
More stuff only makes a very marginal difference.
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