Because of the extensive evolutionary elaboration of neocortex, a structural loss in humans comparable with the severe ablation phenotype is likely to result in gross microtelencephaly, with marginal chances for fetal survival to birth (Jones, 1997; Striedter, 2005).
Even two individual polymorphisms showed differential distribution of variant alleles between cases and controls, the effect nevertheless was marginal and a chance factor could no be ruled.
In case of an asymmetrical distribution of marginal totals, the chance agreement levels are lower which results in higher kappa values [ 44, 45].
Range contraction of widespread species may have left isolated populations in marginal areas, providing chances for peripheral speciation of regional endemics [ 2– 5].
Although culture conditions, including medium composition, temperature, CO2%, and cell-cell interactions, are standardized and the cell micro-environment is expected to be the same across replicas, it is likely that marginal changes happen by chance.
Although SNP rs3804099 and rs3804100 were out of HWE (P = 0.01 - 0.02), we retained them in the analyses as these P values were marginal and may be chance findings and the internal blinded quality-control specimens did not show evidence of genotyping error.
