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GPT neurons migrated radially into the marginal and mantle zones within 24 h of proliferation.
These nascent periods preceded, then briefly accompanied, the subsequent settlement of GPT neurons in the marginal and mantle zones.
Both of these outcomes would have contributed to the early shortfall of live GPT neurons settled distally into the marginal and mantle zones.
Apoptotic GPT neurons which localized with each of the reporters were settled in the marginal and mantle zones of control and ablated mice at E12 P4.
All three reporters demonstrated that GPT neurons settled in the marginal and mantle zones, but only HSV-TK allowed them to be traced back to their immediate progenitors.
Early generated PP (preplate) neurons are leading cells in this assembly, which links the phylogeny and ontogeny of neo-, juxtando- allo-cortexrtex in the telencephalic marginal and mantle zones (Marin-Padilla, 1971, 1998).
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Among mature B-cell malignancies, the most frequent subtypes were plasma cell neoplasms (30%), diffuse large B-cell lymphoma (23%), follicular lymphoma (20%), and CLL/SLL (18%); the 'other' category (9%) included marginal zone and mantle cell lymphomas, and immunoproliferative diseases.
This suggests that the overwhelming sensitivity to chemotherapy is a characteristic that is not present in the native haematopoietic stem cells, but is acquired for ALL, lost for marginal zone and mantle lymphomas, reacquired for diffuse large B cell lymphoma and Hodgkin's lymphoma and then finally lost again later in B cell development.
Increasing evidences suggest that cladribine administered in combination with recently approved novel agents may be a valuable and safe treatment for patients with chronic lymphocutic leukemia (CLL) [ 11, 12] and other lymphoid disorders, such as lymphoplasmacytic lymphoma, marginal zone lymphoma, and mantle cell lymphoma [ 13].
4, 5 Somatic mutations of BIRC3 have also been detected in splenic marginal zone lymphoma 6 and mantle cell lymphoma.
In addition, in chronic lymphocytic leukemia (CLL), marginal zone lymphoma (MZL), and mantle cell lymphoma (MCL), biased usage of IGHV genes and stereotyped clusters of immunoglobulin receptor support the role of antigen-driven mechanisms in their pathogenesis [ 7, 8].
More suggestions(15)
marginal and conditional
marginal and inconsistent
marginal and irrelevant
marginal and average
marginal and reversible
marginal and malleable
marginal and poor
marginal and perverse
marginal and nonsignificant
marginal and canonical
marginal and ineffective
marginal and velamentous
marginal and self-excluding
marginal and questionable
marginal and extreme
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