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The replications of tumour shape, internal enhancement, and margin were treated as classification problems.
Between January 2000 and December 2003, 101 patients with squamous cell carcinoma of the anal canal or margin were treated with CRT.
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Wound margins were treated with lidocaine hydrochloride administered subcutaneously.
Many patients with a presumed worse prognosis, like those with involved margins, were treated with LE+RT outside the trial.
Patients with positive lymph nodes, parametrial involvement, and positive or close surgical margins were treated with adjuvant, postoperative radiotherapy – with or without concurrent chemotherapy.
All five of the implant women who, according to the medical records, had tumour cells in the surgical margins were treated with mastectomy, and four of them also had explantation; for the last case this information was not available.
Tumours that are not appropriate for surgical resection or have positive margins are treated with radiotherapy.
Tumours that are not appropriate for surgical resection or have positive margins are treated with radiation[ 1, 5, 14 ].
For patients with definitive chemoradiation, the tumor and grossly enlarged lymph nodes (CTV1) on CT scan with a margin (PTV1) were treated to 70 Gy in 35 fractions (2 Gy/fraction).
However, this data set used archival specimens, a subset of which did not have clear margins (as they were treated before the benefit of clear margins was proven) therefore, margin status was included in the multivariate analysis of the results.
Between February 2004 and September 2007, 136 consecutive patients with Stage 0/I breast cancer and negative margins ≥0.2 cm were treated on protocol.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com