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Tumour number, largest tumour diameter and surgical margin were determined from standard clinical pathology report, rather than re-review of specimens.
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The shadowing margin is determined such that 90% of the locations on the edge of the cell are covered [30].
The extent of segmental resection with an approximately 10-mm safety margin was determined, and the resection lines were marked on the 3D model (Fig. 2a, b).
This margin is determined based on our total leverage ratio for the preceding four fiscal quarter period, but will be at the highest level at least until we consummate this offering".
Thus, more details are needed in the description on how the NI margin was determined.
Nevertheless, only 106 (45.7%) trials reported the method by which the NI margin was determined.
In 51 (22%) trials, the margin was determined merely based on investigator's assumption.
Putting merely a statement that the margin was determined based on clinically acceptable difference is not sufficient for any subsequent trial replications.
Furthermore, a detailed description on how the margin was determined can help the reader to decide whether the NI margin and the rationale for the margin's choice influenced the validity of the results.
The nature of the invasive margin was determined by haematoxylin and eosin (H&E) histochemistry.
Histological grade and surgical margin was determined as previously described [ 22].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com