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This suggested a healthy margin to achieve the original sample size of 700.
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Although the current recommended management of MIS is wide local excision with a minimum of 5 10 mm margins 4, larger lesions of the head and neck, commonly of the lentigo maligna type, frequently require larger surgical margins to achieve histologic clearance.
The residual gross tumor was boosted with a one cm margin to a achieve a gross total tumor dose of 20 Gy in 2 Gy/fraction or 25 Gy in 1.25 Gy twice a day (bid) for patients with definitive chemoradiation to bring the total gross tumor dose to 70 Gy and 75 Gy respectively.
From their data, they concluded that a 1.5 cm distal rectal wall margin and a 4 cm distal mesorectal margin are necessary to achieve adequate surgical clearance.
The indications for induction chemotherapy included bulky disease, inoperable disease (tumors in which gross clear margin was difficult to achieve), and tumors extending into submasseteric space.
Negative surgical margins are vital to achieve cure and prolong survival in patients with pancreatic cancer.
Though adjuvant radiation therapy is usually reserved for higher-grade tumors in the retroperitoneum where wide surgical margins are difficult to achieve, all subtypes of liposarcoma require complete resection to minimize recurrence [10, 11].
Thus, radical surgery with clear margins was difficult to achieve.
Negative margins are difficult to achieve for ILC with conventional BCS.
If invasive or in situ carcinomas were seen within 2 mm of the surgical margin on microscopic examination (i.e. positive or close tumour margins), a second operation was performed to achieve clear margins.
The margin for this rule to achieve higher channel selectivity order is clearly bound by the second rule.
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CEO of Professional Science Editing for Scientists @ prosciediting.com