Later, at gw 12, staining for COMP became restricted to the margins of the developing epiphysis, the developing joint surface, and the diaphysis of long bones.
cut is transcribed in a narrow strip of cells at the dorsal ventral margin of the developing Drosophila imaginal wing disc, and this transcription requires Notch activity (33).
The Ssq mouse has pre-axial polydactyly and displays ectopic Shh expression at the anterior margin of the developing limb bud (5).
SHH is a morphogen that is produced in a single, restricted domain lying at the posterior margin of the developing limb bud called the zone of polarising activity (ZPA).
In mice, transgenic analysis using a construct containing ∼1.7 kb of murine sequence from Lmbr1 intron 5 [linked to the Hbb (haemoglobin, beta) promoter, LacZ reporter and SV40 polyA signal], showed expression of β-galactosidase in the posterior margin of the developing limb bud in a spatio-temporal manner analogous to normal Shh expression (7).
They represent the most extreme result of the progressive cooling and consequent aridification of global climates during the Cenozoic Era (65.5 million years ago to the present), which also led to the development of savannas and scrublands in the less arid regions near the tropical and temperate margins of the developing deserts.
This analysis revealed that the probability of developing locoregional recurrence was significantly higher for the group with TP53 mutation-positive margins when compared with the group with clear margins (P=0.0001; Figure 1A).
C96-Gal4 is expressed in the prospective wing margin region of the developing wing disc where the ct gene is expressed and, in combination with the UAS-Top2RNAi line, reduces the level of Topo II in the wing imaginal disc cells that give rise to the dorsal-ventral margin (Figure S1B).
The oldest sediments were deposited on the flanks of a rifted continental margin, or passive margin that developed during Cambrian time.
For the first time, the principle of subsidiarity and the doctrine known as "margin of appreciation" - both developed in the court's case-law - would be included in the text of the human rights convention.
