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Moreover, the margin of benefit to risk is quite narrow.
Therefore the margin of benefit potentially gained with additional chemotherapy may be reduced [ 12].
Since the efficacy demonstrated in trials was modest and lower than for other biological agents, the margin of benefit seems to be smaller [ 64, 65].
This reflected the reduced margin of benefit for CE when compared to severe stenosis in the trials [ 3, 4], and the higher surgical complication rates seen in real-life practice [ 21].
Similar(56)
Psychological treatments of ADHD in childhood in combination with medication shows a small margin of additional benefit over medication alone, especially in children with anxiety or other comorbid disorders [ 5].
However, further studies may be required to define the optimal dose of Ara-C to be used in combination with clofarabine and the actual margin of clinical benefit derived from the clofarabine/Ara-C combination as compared with each of the drugs alone.
Cristina Casalinho, chief economist for BPI, one of Portugal's largest banks, thinks that borrowing costs for Portugal will continue to rise, because the government has used up its margin, its benefit of the doubt.
By recharging treated wastewater into suitable aquifers along the coastal margin of Perth, a range of benefits may be achieved including: (1) prevention of saline water intrusion; (2) restoration of groundwater levels; (3) water banking and withdrawal to balance seasonal differences in water supply; (4) improvements in water quality; and (5) flexibility in aquifer management.
Therefore, methods that easily detect tumour margins during the operation might be of benefit.
This report suggests that if negative surgical margins are obtainable, mastectomy could be of benefit in patients with inflammatory breast carcinoma.
Similarly, lake-type sockeye might have colonized pro-glacial lakes at the southern margin of the ice sheets without benefit of the putative colonizing abilities of sea/river-type sockeye.
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CEO of Professional Science Editing for Scientists @ prosciediting.com