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Firstly a margin is added to account for microscopic disease to create the CTV.
These 10 GTVs are fused to form the ITV and then a uniform 5 mm margin is added to create the PTV.
Conventionally, a margin is added to the radiologically defined volume of macroscopic disease and areas considered at risk of microscopic spread.
Once the GTV/CTV have been defined, it then becomes necessary to ensure that a PTV margin is added which will allow confidence in the dosimetric coverage of these target volumes.
Subclinical tumour extension is encompassed by defining a clinical target volume (CTV), and a further margin is added to take into account differences in treatment set up from day to day (PTV).
In turn, a further margin is added around this CTV to account for all the technique-dependent variations such as set-up inaccuracy, internal organ motion and treatment machine parameters, which may result in an inadequate dose coverage of the CTV.
Similar(54)
An additional margin was added if necessary.
An additional superior inferior margin was added for respiratory movement.
For the planning target volume (PTV), another 5-mm margin was added isotropically to the CTV.
An additional 0.5-cm margin was added circumferentially around the PTV to account for radiation beam penumbra.
For the planning target volume (PTV), a 10-mm margin was added isotropically to the CTV (PTV1) and GTV (PTV2).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com