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Moreover, the paper shows that regulation at the intensive margin cannot be considered as a substitute for a regulation at the extensive margin.
Typically, the CTV margin cannot be fully imaged.
If the CTV margin cannot be fully imaged, then this becomes the most difficult margin to be determined.
Thus, exceedance of the 80 125 % margin cannot be directly interpreted as resulting in clinical consequences per se.
If this technique does not seem to be feasible, we would consider the procedure risky, if the caudal margin cannot be injected transtumourally under endoscopic control with the required reliability.
Limb salvage surgery is the preferred treatment for malignant bone tumours in paediatric patients at most institutions; however, amputation still plays a role, especially when a satisfactory surgical margin cannot be obtained, or the residual limb will be non-functional.
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We report details of margin status and distance to margins in the present analysis, but would note that the evaluation of this feature and, in particularly, the measurement of distance to margins cannot be considered precise.
It should be recognized, however, that even the ideal supra-maximum (tumor plus margin) surgical resection is unable to eliminate all tumor tissue and, unlike other solid tumors, "clear margins" cannot be achieved in surgery for GBM.
The He age data are inconsistent with the erosion of a downwarped rift margin, and cannot be explained by a constant post-break-up rate of lateral escarpment retreat across the coastal plain or by constant down-wearing.
As in other studies from the period, we have limited information on margin status that cannot be fully resolved by pathological review (Bijker et al, 2001; Pinder et al, 2010) reflecting the more variable pathological practice encountered earlier in the UK screening programme.
With high-resolution probes, a previously described blurred margin could actually be a spiculated margin with sharp demarcation or a poorly defined margin where the tumour cannot be discriminated from the normal parenchyma.
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