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In fact it may be the first of many to march upstream.
Wet, but determined to get even with the trout, I joined my comrades for the march upstream.
George Washington ordered Sullivan to march upstream the Susquehanna River to join General James Clinton's brigade at the Bradford County town of Tioga (now known as Athens).
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The thawing of the ice which takes longer than the freezing lasts from the end of April (upstream) to the end of May, and the spring drift (about five days in duration) produces considerable ice jams.
Discharges were determined daily, and nutrient parameter concentrations determined once or twice each month upstream and downstream from each of the lakes and reservoirs for three years.
In particular, we show that the upregulation of c-Jun is accompanied by a redox-sensitive activating phosphorylation of JNK, a major c-Jun upstream regulator known to be activated by oxidants and oxidative stress [13,18].
The 5′UTR of the transcript identified in the GI cancer cells by RLM-RACE is GC-rich, with a 60.7% GC content and includes an AUG upstream of the translation start site.
Further studies based on pharmacologic inhibition and RNAi-mediated knockdown of distinct c-Jun upstream regulators are therefore required to gain further insights into the probably complex redox-sensitive molecular machinery that links KRIT1 to the ROS-mediated activation of c-Jun.
However, this new TIS must represent a non-AUG start codon because there is no in-frame AUG triplet upstream of the previously assumed AUG start codon.
This unusually long leader sequence contains mostly adenines and uracils, with three AUG sequences upstream of the Ler AUG start codon.
Interestingly, we found that a new AUG codon upstream of the mutated AUG 1 was generated through a change of cytosine to uracil at position 10 in the non-coding region (C10U) of the AUG 1 KO, AUG 1+2 KO and AUG 1+3 KO mutant viruses that were sequenced at passage 5 (Supplementary Figure S1A).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com