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A Fisher von-Mises kernel is used for smoothing scalp maps with cross-validated bandwidth selection.
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CoMSIA model was also significant with cross-validated coefficient (q2) and conventional coefficient (r2) of 0.636 and 0.986, respectively.
The CoMFA model produced statistically significant results with cross-validated and conventional correlation coefficients of 0.494 and 0.986 respectively.
At the end, 30 predictor-sets together with cross-validated R-squared statistics were kept.
Results: Our models performed well, with cross-validated R values ranging from 0.62 to 0.95.
This approach allows us to design a fully-automated system and to perform repeated trials with cross-validated results.
High AURKA expression was associated with poor OS HRRR 1.55, P<0.01), with a cross-validated average HRR of 1.57 (P=0.02).
PTGS2 expression was also associated with poor prognosis (HRR 1.60; P<0.01) with a cross-validated HRR of 1.63 (P<0.01.63
EGFR expression in CRCLM was associated with poor prognosis (HRR 1.54; P<0.01) with a cross-validated HRR of 1.47 (P=0.03).
This has been confirmed in situations when the external validation sets were well predicted, even with poor cross-validated performance [38].
The CoMFA model with the cross-validated q2 value of 0.735 revealed that the model was valid.
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