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bCellular processes with at least four maps are high-lighted in bold The most prominent transcriptomics-based maps were involved in metabolic processes with amino acid metabolism on top followed by lipid metabolism, steroid metabolism, metabolism of mediators and vitamin and cofactor metabolism.
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The cellular processes in which these 73 pathway maps are involved are presented in Table 3. Cross-omics analysis revealed amino acid metabolism, lipid metabolism, GPCR signaling, Vitamin and cofactor metabolism and transcription to be the cellular processes most dominantly affected in HepG2 by TCDD exposure.
CHF, SSS, EH, MVR and MAP were involved in editing drafts of the manuscript.
MaP was involved in data collection, study design, data analysis and interpretation, and drafting of the manuscript.
Additionally, 36 assigned metabolites could be mapped being involved in 99 toxicity functions (Supporting Information Figure S-17 and Spreadsheet S-3), such as liver damage, cardiac damage, and renal failure.
MAP was involved in the project conception, designed experiments, carried out RNA extraction, performed qRT-PCR and Western blot analysis, performed data analysis, analyzed Illumina data, and drafted the manuscript.
MAP, DGM and PG were involved in critical review of the manuscript.
MAP kinases were involved in apical TGF-β-mediated activation of CTGF synthesis in proximal cells and a subset of epithelial cells of distal origin.
MAP and CEC were involved in the experimental design and conception.
JMG, MAP, MG, and GK were involved in data analysis.
Of these, 6,348 were mapped to GO categories, and were involved with biological processes, molecular functions, and cellular components.
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