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It maps to loci that have previously been shown to be involved in local adaptation to climate.
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Our analyses of GLTPi, which maps to locus 11p15.1 of chromosome 11, provide a clear indication of the challenges associated with definitive validation of pseudogene transcription.
Among trans-mapping effects, only a minority map to loci containing TFs.
By our selection criteria, the two partners of a chimeric sequence map to loci on two different chromosomes.
Simply put, the selection of chimeric sequences consists of selecting queries (EST or mRNA) that map to loci on two different chromosomes.
The percentage of mapped reads mapping to loci of annotated RTEs are shown to the right.
Of these, seven map to loci where common variants probably influence HbA1c levels via erythrocyte biology.
We directly replicated five previously reported European variants (P<0.05; mapping to loci harbouring FASLG/TNFSF18, SCHIP1/IL12A, PFKFB3/PRKCQ, ZMIZ1 and ICOSLG).
The seven most abundant candidates all mapped to loci that were annotated as tRNA or rRNA except Fc-2 (Additional file 2), although some also mapped to other loci that were not annotated.
Exploration of the 57,308 RNA DNA hybrids mapping to intergenic regions revealed 11,825 to map to loci where GRO-seq indicated transcription.
Probes were mapped to loci in Arabidopsis and rice according to the mapping files that were provided by TAIR [ 58] and the Rice Array Database [ 69], respectively.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com