We used the tag maps to infer a methylation signal (black solid line) from the superposition of the top-strand signal (red dashed line) and the bottom strand signal (green dashed line) (Supporting Information S1).
This further demonstrates the inability of the microsatellite maps to infer the correct order of markers.
Contour maps to infer the frequency of each lineage across the country were built using available genotyping data of almost 1,000 M. tuberculosis isolates previously generated [ 9].
Numerous approaches have been applied to co-expression maps to infer gene function information from single tissues, entire organisms or across species [ 13, 14], but they have also been employed to determine the differences and similarities between species [ 15, 16].
Using over 14,000 orthologous genes between human, chimpanzee, mouse rat and dog, we built multiple pairwise synteny maps to infer short orthologous intervals that were targeted for characterizing the canine missing genes.
We cannot, however, directly compare those optical maps to infer the presence/absence of DNA sequences based on the presence/absence of restriction fragments because the restriction fragments are inherently degenerate in the same sense that the genetic code is degenerate.
