Sentence examples for maps of histone from inspiring English sources
Changes in DNA methylation have been investigated in pancreatic cancer [ 9- 11] but genome wide maps of histone modification patterns have not been reported in this disease.
To date, Chromatin Immunoprecipitation coupled with microarray chip (ChIP-Chip) or deep sequencing (ChIP-Seq) is the predominant experimental technology for obtaining genome-wide maps of histone modifications.
To understand the role of epigenetic regulation in establishment and maintenance of HIV-1 latency, the genome-wide maps of histone modifications for H3K4me3 and H3K9ac were obtained in HIV-1 latently infected cell lines and uninfected A3.01 cells.
The integration of these data with maps of histone modification, DNA methylation, co-activator and nucleosome exclusion in cardiovascular tissues will provide a comprehensive view of how the genome is dynamically regulated in health and disease.
Previous genome-wide maps of histone H3 lysine 4 and lysine 27 tri-methylation (H3K4me3 and H3K27me3) showed a very clear correlation between H3K4me3 and expressed genes and H3K27me3 and repressed genes in embryonic stem cells [ 7- 10], T cells [ 11], hematopoietic stem cells/progenitor cells [ 12] and in prostate cancer cells [ 13].
Yu et al. inferred the first epigenetic regulatory map of histone modifications and gene expression [34].
Recently, a technical method for genomic mapping of histone modifications in vivo has been developed, allowing researchers to obtain a broader view of the distributions of histone modifications.
On the other hand, the mapping of histone modifications in the absence of formaldehyde crosslinking offers an opportunity to investigate the dynamic processes of nucleosome remodeling and histone modifications.
However, recent genome-wide mapping of histone modifications indicates that bivalent-modified domains are not only unique to ES cells but also can be found in differentiated cells such as T cells and mouse embryonic fibroblasts (MEFs) [16], [17], [18].
This indicates that the mapping of histone modifications may provide further knowledge about disease progression.
The mapping of histone modifications throughout the genome fulfills these requirements.
