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First they created maps of gene expression by examining individual muscle cells.
To construct dynamic maps of gene interactions (also called genetic regulatory networks) we need to understand the interplay between thousands of genes.
Comparing maps of gene interactions offers insight into how yeast cells repair DNA damage.
It is of interest that the heat maps of gene expression were remarkably similar in six independently derived cell lines following Cr VI) exposure.
For data visualisation, the heat maps of gene expression were created by importing relevant subsets of RMA processed microarray gene expression data into the dChip v1.3 microarray analysis package (http://www.biostat.harvard.edu/complab/dchip/).edu/complab/dchip/
Figure 10 shows overrepresentation maps of gene sets selected from each spot in Table 1.
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Heat maps of genes annotated for inflammation and TGFβ signaling (Supplementary Fig. S1) show transcriptional induction.
Then the two researchers invented a computer algorithm to analyze maps of genes in minutes instead of months.
Heat maps of genes from microarray analysis illustrate patterns of expression that are unaffected by the nutritional environment (Fig. 2C).
(c) Heat map of gene expression in TSA tumours 24 h after radiation in vivo (n=3).
Isolation, characterization, and mapping of gene encoding dihydrolipoyl succinyltransferase (E2k) of human alpha-ketoglutarate dehydrogenase complex.
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