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Maps of cortical thickness showed significant thinning of 28percentt on average across broad expanses of the right cerebral hemisphere in the high-risk group, compared with the low-risk group, the paper reported.
Figure 1 Statistical maps of cortical thinning between psychotic and control subjects.
Figure 2 Statistical maps of cortical thinning between bipolar and control subjects.
This study reports the first comprehensive three-dimensional (3D) maps of cortical patterns in children.
Neurofibrillary tangles accumulate first in transentorhinal and cholinergic brain areas, and 4-D maps of cortical volume changes show early progressive temporo-parietal cortical thinning.
Adjusting the significance threshold to p < 0.001 (two-sided), statistical maps of cortical thickness differences between bipolar, psychosis and controls groups identified eight ROIs (Figures 1 and 2, Table 4, Table S2 in Additional file 1).
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We conclude that for the mapping of cortical areas, the Sydney system is potentially an improvement on Talairach's.
We exemplify the capabilities and versatility of HelioScan by demonstrating several in vivo brain imaging modes, including camera-based intrinsic optical signal imaging for functional mapping of cortical areas, standard two-photon laser-scanning microscopy using galvanometric mirrors, and high-speed in vivo two-photon calcium imaging using either acousto-optic deflectors or a resonant scanner.
Such an extensive mapping of cortical electrophysiology was clearly beyond the scope of the present work, which was primarily aimed at evaluating, technically, the general level of accuracy of TMS/hd-EEG.
An exploratory map of cortical thinning in mild AD was used to define regions of interest that were applied in a hypothesis-driven fashion to other subject samples.
Sample 1a was used to generate an exploratory map of cortical thickness differences between nondemented OC CDRR = 0) and mild AD (CDR = 1) participants.
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