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Shimony has shown that finding MAPs is NP-hard.
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Tzitzikas et al. [6] showed that the problem of finding the optimal mapping is NP-hard in the general case and polynomial in the case where bnodes are not directly connected.
Finding the optimal mapping, however, is NP-hard in the worst case.
Goldman et al. [ 24] showed that the contact map problem is NP-hard.
If this prohibition holds, the problem of building the globally minimal (i.e., globally minimizing the cost functional) mapping of G into S is NP-hard.
DAG Partitioning is NP-hard.
The problem is NP-hard.
Unfortunately, it is NP-hard.
Solving the developed model is NP-hard.
The considered problem is NP-hard.
J-MIN-Seed, unfortunately, is NP-hard.
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