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For each site, we performed an offline analysis of unprocessed unipolar electrograms collected during AF from multipolar basket catheters using the maximum -dV/dt assignment to construct isochronal activation maps for multiple cycles.
Based on the ion intensities obtained from each tissue location, two-dimensional distribution maps for multiple lipids could be simultaneously obtained through one measurement [ 15].
Nevertheless, the generation of genome-wide binding maps for multiple transcription factors across different cell types remains a formidable challenge for individual labs [45].
When multiple species are used, as in this analysis, pairwise homology maps can be utilized to build orthology maps for multiple species, as Mercator will find orthologous segments even if some anchors are missing in one of the species.
Finally, the establishment of linkage maps for multiple pedigrees within a species is also a prerequisite for multiple pedigree-based QTL detection strategies aiming to identify and validate QTLs in a broad genetic background [ 69- 73].
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To provide a definitive linkage map for multiple sclerosis, we have genotyped the Illumina BeadArray linkage mapping panel (version 4) in a data set of 730 multiplex families of Northern European descent.
MALDI imaging was performed in this experiment with a 1 mm pitch and 100 μm diameter laser microprobe, obtaining a coarse chemical map for multiple biologically related ions, including PQS (MH+ at m/ z 260.17), shown in Figure 2B.
Although this provides a comprehensive IBD map for multiple mouse strains for which complete genome sequences are not yet available, the IBD segments defined in this way are coarse as they have been derived using a ~10,300 SNP genotype map, whereas there are more than 2.5 million SNPs reported in the different mouse strains [ 20].
To judge if two MAP values are significantly different or not, we employ the randomization test described in Smucker et al. (2007): for each query, this test randomly reassigns the AvePs achieved by two methods to one another, and computes the difference between the resulting MAP for multiple such reassignments to get a distribution, against which the true MAP value is tested in terms of P-value.
Our objective was to quantify the effects of several scale-related methods on map accuracy for multiple forest attributes, using a variety of diagnostics that address different map characteristics, to help guide map developers and users.
The purpose is to fine map QTLs for multiple traits and to directly and indirectly use the highly recombined lines in breeding programs.
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