bCellular processes with at least four maps are high-lighted in bold The most prominent transcriptomics-based maps were involved in metabolic processes with amino acid metabolism on top followed by lipid metabolism, steroid metabolism, metabolism of mediators and vitamin and cofactor metabolism.
CHF, SSS, EH, MVR and MAP were involved in editing drafts of the manuscript.
MaP was involved in data collection, study design, data analysis and interpretation, and drafting of the manuscript.
Additionally, 36 assigned metabolites could be mapped being involved in 99 toxicity functions (Supporting Information Figure S-17 and Spreadsheet S-3), such as liver damage, cardiac damage, and renal failure.
MAP was involved in the project conception, designed experiments, carried out RNA extraction, performed qRT-PCR and Western blot analysis, performed data analysis, analyzed Illumina data, and drafted the manuscript.
We chose to examine p38-MAPK because it is previously known to be a part of the PI3K/Akt pathway [13] while other MAP kinases are involved in separate [53] or even antagonistic pathways [54].
Mitogen-activated protein (MAP) kinases are involved in mitosis and the regulation of cellular proliferation.
Both JNK and p38 MAP kinase are involved in mechanisms of apoptosis [ 17, 18].
Both p38, ERK1/2 and other MAP kinases are involved in MITF signalling and regulation [ 3, 5, 32].
Mitogen activated protein kinases (MAP kinases) are involved in directing cellular responses to a range of stimuli including viral infection.
