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Figure 5 shows the WER of ESniff MMSR when the reference HMM was selected using the SNR mappings obtained from Table 1.

GO term enrichment analysis on the gene sets of interest was performed using the R package goseq (Young et al., 2010) with custom GO term mappings obtained from org.At.tairGO2ALLTAIRS within the R package org.At.tair.db (Carlson, 2010).

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Disease to gene mappings are obtained from KEGG [ 21], pathway to gene mappings are collected from REACTOME [ 22], drug to gene mappings are obtained by parsing DrugBank [ 23] data, and finally GWAS diseases/traits to genes mappings are collected from NHGRI's GWAS catalog [ 24].

Finally, the set of manually assigned mappings is obtained from the PPDMs resource and used to override mappings that have been assigned by the default procedure.

The full-field displacement mappings obtained by DIC revealed all ranges of cracks, from microscopic to macroscopic, and an image processing procedure was conducted as to quantify their evolution in the course of the degradation of the samples.

Drug-Target mappings were obtained from two sources.

Manually curated atom mappings were obtained from the BioPath database [33] for the 340 Recon 3D reactions that are also on the BioPath database.

To facilitate downstream analysis, Entrez Gene id-to-mRNA accession mappings were obtained from NCBI (the gene2accession file from the Entrez Gene ftp site) and then added to each gene grouping.

GO term mappings were obtained from www.pombase.org.org

All human proteins and their Protein-GO term mappings were obtained from biomart in ENSEMBL (http://asia.ensembl.org/biomart/martview/).org/biomart/martview/

The multiple sequence alignments were constructed with ClustalW2 [61] together with Saccharomyces sequences and orthology mappings obtained elsewhere [46], [62].

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