Given the inferred role of recombination and conversion at the KIR locus, complex orthology mappings are expected, yet previous efforts to establish phylogenetic relationships among primate KIR genes using full protein sequences (Guethlein et al. 2002; Sambrook et al. 2006) are effectively grounded in the X-orthology concept.
Further statistical method development is expected to lead to substantial improvements in fine-mapping causal regulatory variants, and may illuminate novel mechanisms that do not necessarily require disruption of transcription factor binding [ 34].
In these applications, ƒ is expected to behave randomly; Flajolet and Odlyzko study the graph-theoretic properties of the functional graphs arising from randomly chosen mappings.
Limits of sequences of fuzzy sets, and limits and derivatives of fuzzy set-valued mappings can be expected to be useful and important for (i) fuzzy set-valued optimization, (ii) stability theory and sensitivity analysis for fuzzy mathematical models, etc.
As the RDT has been designed with a focus on organic reactions and all algorithms of the RDT rely on substructure matching, incomplete or incorrect mappings can be expected for small molecules.
Instead, in the patients the 'intermediate' haplotypes 2, 3, and 4 are prevalent, and it is these which would be expected to be informative for fine-mapping and functional studies.
Across-breed analyses could facilitate fine-mapping by reducing the length of associated genomic regions, since haplotypes shared across breeds are expected to be shorter than within-breed haplotypes e.g. [ 15, 16].
As expected, relatively few mappings were obtained to the small W chromosome as well as to chromosome 16, a micro-chromosome that harbours the highly variable Major Histocompatibility Complex (MHC), which has been shown to have low synteny between chicken and other birds [ 44– 44].
The sea mappings are actually significantly over-represented (p<10−14), and soil genes map to soil about as often as expected.
As already expected based on the results from other approaches [ 29], only a single or very few reaction mechanisms, i.e., non-symmetric atom mappings, are identifiable, see Table 2 column "Sol".
