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The success of Textpresso in curation of GO subcellular localization (20) is also a good example of helping the curator to find evidence and to create the correct mappings into a terminology or ontology.
In addition, one limitation in the analysis is that it precludes detection of previously unidentified miRNA precursors, an angle which could be addressed by feeding the deep-sequencing data mappings into a miRNA prediction program (based on parameters like mature/star sequence count distribution, folding properties, etc).
Cho et al.[ 32] produced an extension to Rosen's (M,R) system by allowing for mutation, defined simply as alterations to the system while it is in operation, transforming (M,R) from "a description in terms of mappings into a dynamical model familiar to control engineers".
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This method converts a non-self-mapping into a self-mapping such that the classical results can be used.
Such a goal requires incorporating dynamics from each of the sub-mappings into an over-arching set of expectations.
If a read's mappings to two or more pseudogenomes are identical, Suspenders merges the mappings into one logical unit and tags the mapping with a bit vector to identify the origin.
We loaded these pseudochromosome mappings into our own copy of the ATIDB Arabidopsis genome database [ 13] to enable a programmatic analysis.
We divide all possible binary mappings into two mutually exclusive subsets of codon readings.
We then set up the results for manual verification by placing the mappings into the i2b2 Mapper tool, which allows graphical editing and verification of merged ontologies [ 21].
The scheme is based on the idea of decomposition of a global orthogonal transform into consecutive mappings of a conformal mapping and an auxiliary orthogonal mapping, which was suggested by Kang and Leal (J, Comput. Phys.102, 78 (1992)).
Mappings mean going into a house we have no intelligence on.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com