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For local eQTL mapping, we restricted the analyses to SNPs within 1 Mb (500 kb upstream or downstream) of each unambiguously mapped expression reporter sequence.
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We first require a learning algorithm that maps (While we restrict ourselves to the deterministic case for simplicity, bagging is applicable to stochastic learning algorithms as well).
We restricted this mapping to residences within a 5-mile radius of the hot spot.
SNP rs6644913 was removed because it maps to the X chromosome; we restricted our analyses to the autosomes because Fst values from the sex chromosomes are not comparable to autosomal Fst values.
For assessing the performance of MDP-based fine mapping, we decided to restrict the analysis to intervals with strong association signals in both the BXD and MDP datasets.
In order to assess the performance of the MDP-based fine mapping, we decided to restrict the analysis to eQTL with very strong association signals in both the BXD and MDP datasets (see Materials and Methods).
Recombination analysis in two mapping populations restricted the region of interest to approximately 400 Kb.
Two linkage maps were developed and six QTLs were identified on five chromosomes (1, 3, 4, 7 and 8) in the BC1 population by means of the Interval Mapping and restricted Multiple QTL Mapping methods.
Due to craniotomy limits, the spatial extent of DCS language mapping is restricted to cortical regions surrounding the brain lesion and therefore DCS cannot regularly provide the extensive language maps that rTMS provides.
We were able to map DRB1*1501 restricted epitopes by first expanding allergen specific T-cells in vitro by incubating PBMC from DRB1*1501 allergic individuals with recombinant Ves v 5.
In all these studies, although QTL mapping is very successful in detecting QTL, the genetic variation in the mapping population is restricted to only the two parents, and the markers for detected QTL are not necessarily transferable to other materials.
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