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The second combines tonotopic and myeloarchitectonic mapping to localize primary auditory areas in individual healthy adults, using a similar strategy as combined electrophysiological and post-mortem myeloarchitectonic studies in non-human primates.
In the current study, we performed population-based cortical surface mapping to localize AOAs to precise areas of visual cortex with known response properties, in order to elucidate the functional role that AOAs might play during active listening.
We used meiotic mapping to localize me69 to a 6.7-Mb interval on chromosome I (Davis et al., 2005, Tables 1 and 2).
This requires a two-step analysis: genetic mapping to localize the region carrying the mutation (done presently by analysis of strain-specific single nucleotide polymorphism (SNPs)), followed by sequence analysis to detect the causal variant.
Here, we combine lattice light-sheet imaging, single-molecule tracking, numerical simulations, and ChIP-exo mapping to localize and functionally probe Sox2 enhancer-organization in living embryonic stem cells.
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The screening results were cross-referenced with the physical map to localize the positive clones onto contigs.
Knowing all of these limitations, we showed however that a physical map can be a useful complement to a genetic map to localize a set of candidate genes for agronomical traits.
In addition to the aforementioned polymorphism-based BSA mapping, we used a microarray chip mapping approach to localize the mutations on chromosomes (Table 3).
Understanding patterns of linkage disequilibrium (LD) across genomes may facilitate association mapping studies to localize genetic variants influencing complex diseases, a recognition that led to the International Haplotype Mapping Project (HapMap).
The major goal of genetic mapping is to localize genes or QTLs, involved in traits of interest that are linked to molecular markers.
The first involves the fine chromosomal mapping required to localize a mutation to a small genomic region, and the second entails the Sanger-based sequencing of genes within that defined region to find putative mutations.
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