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Bottom panel: proportion of genomic reads mapping to coding sequences (CDS Exons), introns, or untranslated regions (3′ or 5′ UTRs).
Only genetic variants mapping to coding and splice site regions were considered causative.
(B ) Length distributions of reads mapping to coding regions and extensions in human foreskin fibroblasts.
(A ) Length distributions of reads mapping to coding regions and extensions in yeast.
In our study, we found that there were 30,998 bi-allelic SNPs mapping to coding regions, 38.6% of which were previously found and recorded in dbSNP.
We identified 3 GSSPs mapping to coding exon 11 and exon 12 of CNAG_05480, the gene coding for hexokinase, but in a different frame of translation.
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Probes on all platforms were re-mapped to coding sequences in the current version of the mouse genome.
In addition, a small proportion of reads could be mapped to coding sequences, which are likely to be RNA degradation products.
Single nucleotide Polymorphisms (SNPs) were detected by the MUMmer [ 25] and SNPs were mapped to coding regions using PERL scripts.
A second method for evaluating changes in category or pathway prevalence relied on read counts that mapped to coding sequences.
Moreover, small indels mapped to coding regions led to the frame shifts of 74, 72 and 87 genes in BH, HN and S, respectively.
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CEO of Professional Science Editing for Scientists @ prosciediting.com