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Fine mapping this locus in the AJ and African-American populations could help shed light on this question.
Fine mapping this locus and describing its structure thus understanding the sex determination of kelp gametophytes will be the focus of our future studies.
Fine mapping this locus with three CAPS markers derived from the actual MIP genes themselves or sequences nearby did not improve the linkage obtained with the two most closely linked SSR markers.
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We further tested all markers in this region (approximately 500 Kb regions upstream and downstream of BIN1) in QFP and combined all available samples/data (Pfizer, ADNI, GenADA, the replication Genizon samples and the published Harold data set) to fine-map this locus.
Mutmap-like strategy and extreme linkage analysis were then applied to fine map this locus within 1.14 cM.
Based on a resequencing analysis of a 56 kb region on chromosome 19q13.33, centered on the KLK3 gene, we fine mapped this locus by genotyping tag SNPs in 3,522 prostate cancer cases and 3,338 controls from five case control studies.
A region on the right arm of chromosome 3 that is linked to e had the greatest effect, and recent work has fine-mapped this locus to the interval bounded by ∼3:26,136,000 and ∼3:26,315,000 (Hungate et al. 2013).
The sequence of wPt-0223 was used to map this locus in silico at position 2,170,833 bp (i.e. 0.53 Mb proximal of marker cfp5031), just outside the interval predicted in 3B-RH.
A similar study of ancestry-shift refinement mapping of this locus with regards to BMD is warranted in order to pinpoint the underlying signal.
Also for this gene, the UCSC Genome Browser indicates the existence of additional expressed sequences (6 cDNAs and 11 ESTs) mapping to this locus in comparison to the UniGene cluster (12 ESTs).
Many of the Usf1 target genes mapping to this locus may be indirectly affected by the Usf1 allele, i.e. they are not directly regulated via Usf1 binding in their enhancer regions [44].
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