Additionally, our fluorescence mapping studies revealed that the processes of BFL1- and BCLXL-mediated BAX retrotranslocation are communally linked to partial exposure of BAX BH3 motif.
Early mapping studies revealed that Oct4, Sox2 and Nanog co-bind gene promoters of many mESC and hESC genes [ 23, 24].
Nucleosome mapping studies revealed global effects of RSC and ISW1a complexes acting against each other in shaping the promoter chromatin architecture.
Genetic mapping studies revealed clusters of congruent or overlapping QTL on LG 2 and 17 that control eye size, VAB and the number of EO SN.
Our mapping studies revealed over 18,000 Alu-DR2 elements lying within -10 kb and +10 kb of the 5'ends of >10,000 genes, [see Additional file 2], representing a substantial proportion of human genes.
In total, the mapping studies revealed five QTLs on chromosomes 2, 5, distal 16, 17 and 19 (Qivr5-2, Qivr16 Qivr16, Qivr17-2 and Qivr19) that did merit further analysis because they were consistently observed in at least two traits and exerted an effect on at least two different days p.i.
Such mapping studies reveal that genetic associations with gene expression are common, that they often have large effect sizes, and that regulatory variants act locally and at a distance to modulate a range of regulatory epigenetic processes, often in a highly context-specific manner [ 5].
Furthermore, fate-mapping studies revealed migration of airway epithelial cells into the sub-epithelial regions of the airway wall.
Increased mapping resolution in our study revealed that some of the previously identified coincidences among QTL for horticultural and resistance traits in Brouwer and St. Clair (2004) were most likely attributable to tight linkage, rather than to pleiotropy.
QTL mapping strategies adopted in this study revealed complementary results for single and multiple traits with high accuracy.
