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In this study, a pharmacophore mapping studies were undertaken for a series of phenylaminopyrimidines derivatives.
To reveal novel insights into the inhibition of BCR-ABL tyrosine kinase, pharmacophore mapping studies were performed for a series of phenylaminopyrimidine-based (PAP) derivatives, including imatinib (Gleevec).
Predictive and validated regression models (2D and 3D QSAR and ligand-based pharmacophore mapping studies) were utilized for estimating the potency whereas classification models (Bayesian and recursive partitioning analyses) were used for determining the selectivity of MMP-2 inhibitors over MMP-9.
In vitro autoradiography mapping studies were performed on human and rhesus monkey.
Although structural mapping studies were less informative than hoped, the results indicate that the A-sheet and RCL are likely to be involved.
Finally, recent mapping studies were able to detect more QTLs of small effect using large populations [20], [21], but epistasis between or among QTLs were not adequately addressed in these studies and phenotyping large populations poses a tremendous challenge, particularly across multiple environments.
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Systematic mapping studies are used to structure a research area, while systematic reviews are focused on gathering and synthesizing evidence.
Hence, the activity of formulating research questions in mapping studies is ill-defined, rendering it difficult for researchers who are new to the topic.
Systematic literature reviews and systematic mapping studies are becoming increasingly common in software engineering, and hence it becomes even more important to better understand the reliability of such studies.
The mapping studies are summarised in Additional file 3.
A major constraint to previous QTL mapping studies is the number of available polymorphic markers.
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