Sentence examples for mapping studies using from inspiring English sources

For these reasons, mapping studies using SSR markers usually include many more markers than those using RFLP markers.

However, a series of recent fate mapping studies using different epithelial and mesenchymal tags showed no evidence of epithelial precursors to myofibroblasts in the kidney and liver suggesting an alternate precursor cell type or that the role of the epithelium in fibrogenesis may be organ or disease specific [64, 73 77].

To provide additional insight into the mechanism of BRCA1 downregulation, we conducted functional mapping studies using expression constructs encoding BRCA1 variants lacking major functional domains (Fig. 5A).

The epitope mapping studies using tryptic fragments of porcine ZPC followed by sequencing and mimotopes strategy revealed that MA-467 recognized the peptide corresponding to QPVWQDEGQRLR sequence (aa 23-34) of ZPC that is in the N-terminal part of the mature, secreted porcine ZPC.

This conclusion is in contrast to our previous fate mapping studies using a BAC transgenic Ascl1::CreER™ mouse, where essentially all lineage marked cells differentiated to mature neurons within 30 days in the SVZ and the SGZ, which suggested that in this paradigm Ascl1 lineage cells are restricted to the transit amplifying populations [7].

Adequately powered rare variant mapping studies using these new, denser, GWAS chips are therefore going to be very expensive.

Systematic mapping studies use the same basic methodology as an SLR; however, they aim to identify all the research related to a specific topic and classify the primary research papers in that specific domain, rather than addressing the specific questions that a conventional SLR addresses (Kitchenham et al.2010).2010

Association mapping studies use unpedigreed mapping to look for associations between traits and markers, either using a candidate gene approach or genome-wide markers (GWAS studies) (Box  1).

A mapping study using 65 F2 plants generated by the selfing of one interspecific cross A. cepa × Allium roylei individual integrated the SCAR marker SAOE17500 into chromosome 5 as expected.

This was followed by a fine-scale physical mapping study using 4,022 F2 individuals, narrowing the locus to 0.075 cM (150 kb; six recombinants; Xu et al. 2006).

Consequently, we initiated a linkage and association mapping study using half a million genome-wide single nucleotide polymorphisms (SNPs) in a common set of 1,031 multiplex autism families (1,553 affected offspring).