Exact(3)
An across breed mapping strategy has been successfully used to map traits including coat pattern in dogs, a species with a similar pattern of linkage disequilibrium to cattle [23].
The association mapping strategy has been proposed to identify polymorphisms involved in phenotypic variations and may prove useful in identifying interesting alleles for breeding purpose.
Although a preliminary genetic linkage map for M. sinensis using RAPD markers and an "offspring cross" mapping strategy has been published [ 17], this map resolves 28 linkage groups (LGs), many more than the expected 19 LGs.
Similar(57)
At both low and high error rates, all three strategies achieved similar FNR as the no-contamination case, and only the direct mapping strategy had a higher FDR.
It is worth noting that even though the 60 ×:60 × set contained more reads than the 30 ×:30 × set at the same contamination level, the variants identified by the direct mapping strategy had a higher FDR from the former, which suggests that when this strategy is used, producing more reads may not help when the contamination level is high.
The bin-mapping strategy has been shown to be superior in detecting and fine mapping QTLs versus traditional methods [ 31– 31].
Both candidate gene and QTL mapping strategies have been used in domestic animals for the discovery of genetic markers suitable for MAS [3].
In Arabidopsis, effective tag to gene mapping strategies have been assisted by the completion of the genome sequence where approximately 30,000 gene models have been identified [ 19].
In addition, studies of diet-induced bone loss using QTL mapping strategies have found evidence for sex-specific variant effects [ 216].
Mapping strategies have also progressed from simple interval mapping (SIM) to more complex composite interval mapping (CIM), multiple QTL mapping (MQM), and others which greatly increase the accuracy of placing QTL [ 7].
Very recently, joint linkage-association mapping strategies have been proposed to utilize each method [ 7, 8], including parallel mapping (independent linkage and LD analysis) [ 9- 13] and integrated mapping (dataset analysis in combination), such as MAGIC (Multi-parent advanced generation inter-crosses) [ 14] and NAM (nested association mapping) [ 15].
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