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This loss of mapping precision is undoubtedly a drawback of adopting the Standard InChI as the key for defining chemical uniqueness in this situation.
Our assessment of mapping precision is tailored to the particular QTL found in this study.
This is the closest methodology to ChIP-seq, but its mapping precision is lower, and the dynamic range of the readout is significantly less.
However, because linkage disequilibrium is high in such crosses, QTL mapping precision is unsatisfactory and only a few QTL have been found to segregate within outbred strains, which limits their use to improve animal performance.
In our study, the mapping precision is limited due to the LD structure observed in this population (Qanbari et al. 2010) in combination with the applied single marker association analysis.
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(Corresponding estimates of QTL mapping precision are displayed in Figure S6).
Therefore, although the result showed that mapping precision was quite good, even without using these additional sources of information, the use of more sophisticated methods may remove the biases observed in this study when estimating QTL effect and location.
The map expansion results (Table 5 and Figure 3) indicate the accumulation of recombination events over generations, which can be valuable for study design: If an investigator intervenes at an intermediate generation to speed up the process toward inbreeding, what proportion of the final recombination breakpoints might be lost, and so to what extent might mapping precision be eroded?
Locating power and mapping influence with real precision is a complex task in relatively open societies like Britain's, and this article provides just a snapshot.
In the presence of long-range LD, fewer markers are required for mapping purposes, but mapping precision will be low.
Precision is the fraction of mapped reads that are correctly mapped and recall is the fraction of correctly mapped reads that are retrieved.
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