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The results of these simulations are presented in Figure 2 and reveal that the choice of the intermediary data set has a profound influence on mapping precision and recall.
Experimental mapping populations with increased mapping precision and greater genetic diversity are desirable to improve the performance of QTL mapping studies.
As compared to AFLP and other types of dominant markers, these codominant SNP gene markers mapped at such high density will contribute towards improving QTL mapping precision and power [ 72].
Chromosomal regions with shared QTLs across different populations generally correspond to greater mapping precision and greater QTL significance compared to other genomic regions with QTLs discovered from single mapping populations [ 37, 78].
Heterogeneous stocks (HS) derived from multiple inbred founder strains and maintained as outbreeding populations for many generations can increase mapping precision and introduce additional genetic diversity (Li and Lumeng 1984; Hitzemann et al. 1994; Iancu et al. 2010).
Although the number of mapped markers used here for GWAS (957) is among the highest reported for similar studies in wheat, it is also evident that reaching higher mapping precision and complete genome coverage (inter-marker LD r values = 0.8, [ 63]) will require a marker density at least ten times higher, even in cultivated germplasm.
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Fine-grained population mapping, precision vaccination campaigns, and monitoring the backbone of the eradication initiative are out of the question.
This is the closest methodology to ChIP-seq, but its mapping precision is lower, and the dynamic range of the readout is significantly less.
However, because linkage disequilibrium is high in such crosses, QTL mapping precision is unsatisfactory and only a few QTL have been found to segregate within outbred strains, which limits their use to improve animal performance.
One concern is that segregation distortion may affect the recombination frequencies and thus impede mapping precision in map construction and QTL detection.
Here, we performed whole exome sequencing (WES) and canine high-density (cHD) SNP genotyping of 28 dogs from 3 breeds to compare the SNP and linkage disequilibrium characteristics together with the power and mapping precision of exome-guided GWAS (EG-GWAS) versus cHD-based GWAS.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com