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Such additive mapping of identifiers is only useful, however, if the different input identifiers do not all yield the same outputs, i.e., if queries with different input identifiers are independent.
Protein accession numbers and gene IDs were converted to gene symbols using Ingenuity Pathway Analysis IPAA) software to eliminate potential redundancy and incomplete mapping of identifiers.
When deep sequencing data is produced without a fully sequenced genome that reads can be mapped to, SeaSight can still be used for analyses given a mapping of identifiers for the measured transcription levels.
Here, we present CRONOS, a versatile tool for mapping of identifiers, gene names and protein names from various resources like UniProt, RefSeq and Ensembl (Flicek et al., 2008).
Manual inspection of potentially error-prone terms resulted in organism-dependant lists of ambiguous gene and protein names which are not only required for accurate mapping of identifiers but also for bioinformatics applications like text mining.
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More recent adopters include OpenPHACTS (11) (in the mapping of chemical identifiers from different datasets), Bio2RDF (12) (which provides identifiers.org URIs in their Resource Description Format (RDF) data), PSICQUIC (13) (in their BioPAX export) or the European Bioinformatics Institute (when providing data sets in RDF).
Mapping of UniGene identifiers to corresponding GO terms EASE [24] program served to identify all of the BP and MF GO terms that are represented on the human 1.0 ST Exon array.
The clean mapping of structural identifiers (names, CASRN) to chemical structures, with a quality control annotation, provides an essential underpinning to cheminformatics workflows in the Dashboard.
We thank Andrew Spiers, Rob Edwards, Dave Ussery, Chris Taylor, Peter Sterk, Mike Allen, Anil Wipat, Alice MorningStar, Lisa Crossman, Jack Gilbert and Sarah Turner for critical reading of the manuscript and Keith Keller for mapping of unique identifiers for use in the MicrobesOnline database [27].
The mapping of protein identifiers across multiple databases has made the dataset easier to use.
KEGG pathways and the mapping of KEGG identifiers to external references are retrieved via the KEGG FTP server.
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