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Dali-Youcef, N. et al. Gene expression mapping of histone deacetylases and co-factors, and correlation with survival time and 1H-HRMAS metabolomic profile in human gliomas.
Tropberger, P. et al. Mapping of histone modifications in episomal HBV cccDNA uncovers an unusual chromatin organization amenable to epigenetic manipulation.
This is in sharp contrast to the organization of chromatin in human nuclei where two compartments corresponding to open and closed chromatin domains are evident at megabase resolution20, but is consistent with cytogenetic mapping of histone marks associated with heterochromatin in large, repeat-rich genomes29.
Recently, a technical method for genomic mapping of histone modifications in vivo has been developed, allowing researchers to obtain a broader view of the distributions of histone modifications.
However, recent genome-wide mapping of histone modifications indicates that bivalent-modified domains are not only unique to ES cells but also can be found in differentiated cells such as T cells and mouse embryonic fibroblasts (MEFs) [16], [17], [18].
On the other hand, the mapping of histone modifications in the absence of formaldehyde crosslinking offers an opportunity to investigate the dynamic processes of nucleosome remodeling and histone modifications.
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Yoshida, K. et al. Mapping of histone-binding sites in histone replacement-completed spermatozoa.
Hall, M. A. et al. High-resolution dynamic mapping of histone-DNA interactions in a nucleosome.
The mapping of histone-like TAFs in yeast TFIID revealed that these TAF pairs are organized in three distinct lobes within TFIID [20] and not in a single octamer-like structure as previously suggested.
By generating maps of histone modifications at promoters and enhancers in several different human cell lines, it has been possible to determine that although modification patterns at promoters are largely invariant between cell types, the patterns at most enhancers are specific to a single cell type and correlate well with cell-type-specific gene expression.
Yu et al. inferred the first epigenetic regulatory map of histone modifications and gene expression [34].
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