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Comprehensive transcriptional and chromatin mapping of highly pure endodermal populations revealed that endodermal enhancers existed in a surprising diversity of "pre-enhancer" states before activation, reflecting the establishment of a permissive chromatin landscape as a prelude to differentiation.
In polyploid crops, however, accurate SNP detection becomes challenging due to the ambiguous mapping of highly similar homeologous loci, which increases the false-positive rate of detected SNPs.
Structural mapping of highly conserved positions again recovers the starting pattern, although a few β-sheet-associated glycines have been replaced by charges on the most exposed loops.
Other issues include biases resulting from the mapping of highly repetitive regions (Treangen and Salzberg 2011) and biases inherent in the sequencing protocol, for example, GC bias (Dohm et al. 2008) and PCR amplification bias (Aird et al. 2011).
The mapping of highly correlated phenotypes such as the relative content of total, saturated and unsaturated fat and lipid to protein ratio to the same narrow chromosomal region on Chr 12 suggests pleiotropic gene effects.
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The first research question is whether the HSM can produce an accurate map of highly attractive places at a national level.
Assessing wildfire risk entails the integration of fire modeling outputs, maps of highly valued resources and assets (HVRAs), characterization of fire effects, and articulation of relative importance across HVRAs.
Hence, it would be expected that circuits operating at the state ON were preferentially based on I3-FFL and I4-FFL and were present within the regulatory map of highly demanded biological functions, such as central metabolism or transcription-translation machinery.
In silico ground-truthing would be particularly useful for biome maps of highly environmentally heterogeneous areas such as the Andes.
Figure 3B shows the irregular coverage pattern in BCL2 from non-mutated controls (black line) compared to that observed for initial mapping of a highly mutated, highly heterogeneous tumor specimen FL-128 (blue circles), in which reduced local coverage correlates with mutational load.
Mapping of these highly significant SNPs onto the surface of the capsid did not, however, suggest any higher order, biological correlations.
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