Sentence examples for mapping of genome from inspiring English sources
Currently, physical mapping of genome with large-insert clones such as Bacterial Artificial Chromosomes (BACs) and fosmids by fingerprint analysis is becoming an active area of genomics research [5].
Therefore, strategies for the mapping of genome organization and gene transcription in M. hyopneumoniae can help understand regulatory mechanisms and form the basis for future work on mapping promoters and terminators.
The metabolic analysis of the C. aurimucosum ATCC 700975 genome was performed with the computer program CARMEN that provided an automatic mapping of genome annotations on manually curated metabolic pathway maps [ 35].
Here, use of the Capture-C approach [ 36] developed by Hughes and colleagues holds considerable promise: this high-throughput approach enables mapping of genome-wide interactions for several hundred target genomic regions spanning expression-associated variants and putative regulatory elements at high resolution.
The mapping of genomes, he said, inspired scientists to use the same approach in studying proteins, metabolites and their biochemical connections, to name a few.
"Genomics", which refers to the multidisciplinary technology developed to determine the structure, function, evolution, and mapping of genomes was the initial "omic" [1].
These advancements have allowed for very precise mapping of genome-wide epigenetic profiles.
Analyses using high-density genomic tiling arrays or massively parallel DNA sequencers have led to the high-resolution mapping of genome-wide nucleosome positions [11] [22].
Although this approach resulted in successful mapping of genome-wide DNA methylation profiles it suffered from some limitations, including low resolution arrays, as well as an indirect approach for detection of differentially methylated genes between cell lines.
Recently, the fine-scale mapping of genome-wide human recombination hotspots was performed.
The ChIP assay not only allows quantitative detection of a given protein on a particular DNA site but also permits the mapping of genome-wide DNA-protein interaction.
