The Collaborative Cross (CC) is a next-generation mouse genetic reference population designed by the mouse genetics community for high resolution mapping of genetic factors of relevance to human health, such as susceptibility to infectious and chronic diseases, and response to medical interventions.
Due to their combinatorial nature, the mapping of genetic interactions is highly labor-intensive even in genetically amenable organisms.
Shen, J. P. et al. Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.
Dixon, S.J., Costanzo, M., Baryshnikova, A., Andrews, B. & Boone, C. Systematic mapping of genetic interaction networks.
One way to perform linkage-disequilibrium (LD) mapping of genetic traits is to use single markers.
Lehner, B., Crombie, C., Tischler, J., Fortunato, A. & Fraser, A. G. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways.
Using the map of genetic modifiers of H3K14 acetylation (aceQTL), we distinguished the genetically controlled H3K14ac SNEPs from those for which no genetic control was found.
An integrated map of genetic variation from 1,092 human genomes.
Genome-Wide Association Data Reveal a Global Map of Genetic Interactions among Protein Complexes.
Rauscher, B. et al. Toward an integrated map of genetic interactions in cancer cells.
Abecasis, G. R. et al. An integrated map of genetic variation from 1,092 human genomes.
