Sentence examples for mapping of fragile from inspiring English sources
This limitation of our study demonstrates the need for further work in this area and for a more specific mapping of fragile sites.
Moreover, genome-wide mapping of fragile sites revealed a nonrandom distribution correlating with motifs that pause DNA replication forks, including replication-termination sites and binding sites for the helicase Rrm3 (Song et al. 2014).
Therefore, by demonstrating that breakpoints in over half (52%) of the gene pairs co-map to fragile sites, these results provide strong evidence to support a role for fragile sites in the generation of cancer-specific translocations.
In addition, the majority of breakpoints in a papillary thyroid carcinoma rearrangement mapped to fragile sites occur at microhomology patches, indicating that fragile site-associated rearrangements can also arise by microhomology-mediated SSA [ 42].
The most intriguing finding from this study is that the majority (65%) of fragile sites mapped to translocation breakpoints are common fragile sites, which are present in all individuals, and can be induced by a variety of environmental factors and chemical agents.
Due to the availability of extensive databases containing chromosome abnormalities found in various types of tumors, and the increasing number of fragile sites being mapped, we have compiled a table of recurrent translocations in which each participating gene set generates cancer-specific fusion transcripts, and mapped their breakpoints to fragile sites.
There are also around 60 maps and plans of the excavation site, plus hundreds of fragile pages from Carter's journals and diaries.
Their scalps were like maps of alopecia (loss of hair and baldness) and tufts of fragile hair and they were devastated by ringworm (fungus).
Here we present the complete mapping of the human miRNA genes on fragile sites, cancer-specific translocation breakpoints, repetitive sequences and CpG islands.
While these maps can theoretically improve map length and assembly accuracy, added efforts and cost are required with the former approach and the number of fragile sites are increased with the latter approach.
Both contain arrays of fragile elements.
