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Therefore, in addition to the true mapping of expression to lines, we generated 10,000 mappings where line labels were randomly permuted with respect to expression measures.
We performed mapping of expression quantitative trait loci (eQTLs) with WGS and RNA-seq, and found that lead eQTL variants called with WGS were more likely to be causal.
Integration of transcriptional profiling with genotyping data in segregating populations allows linkage mapping of expression quantitative trait loci (eQTL) [1], [2].
Birds-eye-view of overall mapping of expression values were depicted by heatmap, a color-bar created by the range of values in the conditions of the interpretation (Fig. 3B).
These panels also allow genetic mapping of expression QTLs.
BM and JH had implemented the mapping of expression data to pathways.
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Veyrieras, J.-B. et al. High-resolution mapping of expression-QTLs yields insight into human gene regulation.
This approach has previously been highly informative for genome-wide mapping of expression-associated SNPs using resting HapMap LCLs (31– 33), notably for individuals of African ancestry in whom high levels of haplotype diversity facilitates fine mapping of SNP associations (34).
b, Heat map of expression of IAP genes in six tissues.
These results illustrate discrepancies in dystrophin isoforms expression between human and mouse brains and highlight the importance of comprehensive maps of expression in mouse and human brains for better translation between animal experiments to human conditions in which the DMD gene is implicated.
(B) Heat map of expression pattern of all cycling genes in the pathway with the gene ID and reaction of the pathway.
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